[public-health] INFANTS : INFANCY : NEWBORNS : EARLY CHIIDHOOD : MEDICAL: INFECTIONS : MEDICAL: DISEASES: OBESITY: Infection, Not Antibiotic Use, Linked to Childhood Obesity Risk

 

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INFANTS : INFANCY : NEWBORNS : EARLY CHIIDHOOD :

MEDICAL: INFECTIONS :

MEDICAL: DISEASES: OBESITY:

Infection, Not Antibiotic Use, Linked to Childhood Obesity Risk

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Infection, Not Antibiotic Use, Linked to Childhood Obesity Risk

Li DK, et al. Lancet Diabetes Endocrinol. 2016

doi:10.1016/s2213-8587(16)30281-9.

November 11, 2016

Regina Schaffer

Healio

http://www.healio.com/endocrinology/obesity/news/in-the-journals/
%7B2633dea1-eeed-48bf-80ee-6d92f79def19%7D/infection-
not-antibiotic-use-linked-to-childhood-obesity-risk

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A shorter URL for the above link:

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http://tinyurl.com/jhhmph6

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Infection without antibiotic use in infancy is associated with an increased risk for childhood obesity, whereas both broad- and narrow-spectrum antibiotics were not associated with an increased obesity risk, according to findings from a longitudinal birth cohort study.

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To isolate the effect of antibiotic use, we compared antibiotic users with those who had similar underlying infection diagnostic codes but who did not use antibiotics, De-Kun Li, MD, senior research scientist at the Kaiser Foundation Research Institute at Kaiser Permanente Northern California, and colleagues wrote. We used several analytical methods, including propensity score, and our findings showed that once underlying infection types and severity are controlled for, exposure to antibiotics in infancy overall is not associated with an increased risk of childhood obesity, whereas infection during infancy was associated with an increased risk. The association between infection and childhood obesity was further supported by a clear doseresponse relation.

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While there are many other reasons for deciding whether antibiotics should be used, in the context of preventing childhood obesity, treating infant infections with antibiotics is not likely to increase childhood obesity, Li told Endocrine Today. In fact, not treating infections in infancy could increase the risk of childhood obesity that you are worried about.

Regina Schaffer

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The complete article may be read at the URL above.

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Infection and antibiotic use in infancy and risk of childhood obesity: a longitudinal birth cohort study

Dr Prof De-Kun Li, MDcorrespondencePress enter key for correspondence informationemailPress enter key to Email the author, Hong Chen, MPH, Jeannette Ferber, MPH, Roxana Odouli, MSPH

Published: 01 November 2016

Article has an altmetric score of 274

DOI: http://dx.doi.org/10.1016/S2213-8587(16)30281-9

Lancet

http://www.thelancet.com/pdfs/journals/ landia/PIIS2213-8587(16)30281-9.pdf

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A shorter URL for the above link:

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http://tinyurl.com/god5bxm

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Summary

Background

Data from previous studies have suggested a possible association between antibiotic use in infancy and risk of childhood obesity, with implications for health-care delivery and obesity prevention strategies. However, whether the observed association was due to antibiotic use or underlying infection, or both, is unclear. We aimed to disentangle the effect of antibiotic use in infancy from that of underlying infection on the risk of childhood obesity.

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Interpretation

Infection, but not antibiotic use, during infancy is associated with risk of childhood obesity. This finding will need to be replicated in future studies. Although our results do not rule out a potential effect of antibiotics on microbiome composition and the use of antibiotics should always be judicious, they suggest that treatment of common infections with antibiotics in infancy is unlikely to be a main contributor to childhood obesity.

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Additional Reading

Forrest, Christopher B., Jason P. Block, and L. Charles Bailey. “Antibiotics, infections, and childhood obesity.”
The Lancet Diabetes & Endocrinology (2016).

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[public-health] INFANTS : INFANCY : NEWBORNS : EARLY CHIIDHOOD : MEDICAL: INFECTIONS : MEDICAL: DISEASES: OBESITY: Infection, Not Antibiotic Use, Linked to Childhood Obesity Risk

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