[Net-Gold] SPORTS MEDICINE : MEDICAL: CONDITIONS: OBESITY : MEDICAL: DISEASES: DIABETES : MEDICAL: DISEASES: ALZHEIMERS : MEDICAL: RESEARCH : STUDIES: Not Just Diabetes and Obesity. Excess Sugar Intake May Also Cause Alzheimer’s Disease

 

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SPORTS MEDICINE :

MEDICAL: CONDITIONS: OBESITY :

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Not Just Diabetes and Obesity.
Excess Sugar Intake May Also Cause Alzheimer’s Disease

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Not Just Diabetes and Obesity.
Excess Sugar Intake May Also Cause Alzheimer’s Disease

Updated: Feb 25, 2017 15:11 IST

Those who consume high sugar diets may be more susceptible to Alzheimers disease, says a new study.

HEALTH AND FITNESS

Hindustan Times

http://www.hindustantimes.com/health-and-fitness/
not-just-diabetes-and-obesity-excess-sugar-intake-
may-also-cause-alzheimer-s-disease/story-fnqRO0lBC3ZkG5hdw5zyaJ.html

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A shorter URL for the above link:

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http://tinyurl.com/gokovpb

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ALSO

Henry Bodkin

23 FEBRUARY 2017  11:31AM

The Telegraph

http://www.telegraph.co.uk/science/2017/02/23/
alzheimers-could-caused-excess-sugar-new-study-finds-molecular/

OR

http://tinyurl.com/j27yj8v

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People who eat diets high in sugar may be at an increased risk of Alzheimers disease, a new study has warned.

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For the first time a tipping point molecular link between the blood sugar glucose and Alzheimers disease has been established by scientists from the University of Bath and Kings College London in the UK.

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They have shown that excess glucose damages a vital enzyme involved with inflammation response to the early stages of Alzheimers. Abnormally high blood sugar levels, or hyperglycaemia, is well-known as a characteristic of diabetes and obesity, but its link to Alzheimers disease is less familiar.

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Diabetes patients have an increased risk of developing Alzheimers disease compared to healthy individuals.

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snip

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By studying brain samples from people with and without Alzheimers using a sensitive technique to detect glycation, the team discovered that in the early stages of Alzheimers glycation damages an enzyme called MIF (macrophage migration inhibitory factor) which plays a role in immune response and insulin regulation.

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MIF is involved in the response of brain cells called glia to the build-up of abnormal proteins in the brain during Alzheimers disease, and the researchers believe that inhibition and reduction of MIF activity caused by glycation could be the tipping point in disease progression.

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It appears that as Alzheimers progresses, glycation of these enzymes increases.

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snip

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Normally MIF would be part of the immune response to the build-up of abnormal proteins in the brain, and we think that because sugar damage reduces some MIF functions and completely inhibits others that this could be a tipping point that allows Alzheimers to develop, said van den Elsen.

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The complete article may be read at the URL above.

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Macrophage Migration Inhibitory Factor is subjected to glucose modification and oxidation in Alzheimers Disease

Omar Kassaar, Marta Pereira Morais, Suying Xu, Emily L. Adam, Rosemary C. Chamberlain, Bryony Jenkins, Tony James, Paul T. Francis, Stephen Ward, Robert J. Williams & Jean van den Elsen

Scientific Reports 7, Article number: 42874 (2017)

doi:10.1038/srep42874

GlycobiologyProteomic analysis

Received:

05 August 2016

Accepted:

16 January 2017

Published online:

23 February 2017

Abstract

Glucose and glucose metabolites are able to adversely modify proteins through a non-enzymatic reaction called glycation, which is associated with the pathology of Alzheimers Disease (AD) and is a characteristic of the hyperglycaemia induced by diabetes. However, the precise protein glycation profile that characterises AD is poorly defined and the molecular link between hyperglycaemia and AD is unknown. In this study, we define an early glycation profile of human brain using fluorescent phenylboronate gel electrophoresis and identify early glycation and oxidation of macrophage migration inhibitory factor (MIF) in AD brain. This modification inhibits MIF enzyme activity and ability to stimulate glial cells. MIF is involved in immune response and insulin regulation, hyperglycaemia, oxidative stress and glycation are all implicated in AD. Our study indicates that glucose modified and oxidised MIF could be a molecular link between hyperglycaemia and the dysregulation of the innate immune system in AD.

Nature

http://www.nature.com/articles/srep42874

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[Net-Gold] SPORTS MEDICINE : MEDICAL: CONDITIONS: OBESITY : MEDICAL: DISEASES: DIABETES : MEDICAL: DISEASES: ALZHEIMERS : MEDICAL: RESEARCH : STUDIES: Not Just Diabetes and Obesity. Excess Sugar Intake May Also Cause Alzheimer’s Disease

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