[SportMed] PHYSICAL EXERCISE AND FITNESS : MEDICAL CONDITIONS OBESITY : MEDICAL GENETICS : MEDICAL RESEARCH: Physical Activity Helps to Counteract Weight Gain from Obesity-Causing Gene Variant

 

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PHYSICAL EXERCISE AND FITNESS :

MEDICAL CONDITIONS OBESITY :

MEDICAL GENETICS :

MEDICAL RESEARCH:

Physical Activity Helps to Counteract Weight Gain
from Obesity-Causing Gene Variant

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Physical Activity Helps to Counteract Weight Gain
from Obesity-Causing Gene Variant

Study used meta-analyses that account for physical activity
and identified 11 novel obesity variants

Date: April 27, 2017

Source: PLOS

Science Daily

Science News

https://www.sciencedaily.com/releases/2017/04/170427141743.htm

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Summary:

Physical activity can reduce the weight-gaining effects of the
genetic variant that carries the greatest risk of obesity, report.

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Physical activity can reduce the weight-gaining effects of the genetic variant that carries the greatest risk of obesity, report Mariaelisa Graff of the University of North Carolina at Chapel Hill, Tuomas Kilpelnen of University of Copenhagen and colleagues April 27th, 2017 in PLOS Genetics.

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With people consuming more calories and being less physically active, the world has witnessed an obesity epidemic, but not everyone is gaining weight. Previous studies suggest that a person’s susceptibility to becoming obese can be reduced by physical activity. To see how physical activity and genetic variants related to obesity interact to affect weight gain, Graff and colleagues performed genome-wide interaction meta-analyses using more than 200,000 individuals. They categorized individuals as active or inactive, screened them for about 2.5 million genetic variants and correlated that data with physical indicators of obesity, including body mass index, waist circumference and waist-to-hip ratio. The study finds that physical activity can reduce the weight-gaining effects of the strongest known genetic risk factor for obesity, the FTO gene, by about 30%. Accounting for physical activity also enabled the researchers to identify 11 novel genetic variants linked to obesity, suggesting that physical activity and other relevant environmental factors should be considered when looking for novel genes.

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The meta-analyses confirm previous findings that physical activity reduces the effect of the FTO gene, but the underlying cause of this interaction is still unknown.

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The complete article may be read at the URL above.

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[SportMed] PHYSICAL EXERCISE AND FITNESS : MEDICAL CONDITIONS OBESITY : MEDICAL GENETICS : MEDICAL RESEARCH: Physical Activity Helps to Counteract Weight Gain from Obesity-Causing Gene Variant

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