Nassar-MSU Scandal Puts Professional Licenses of 7 Under Scrutiny

 

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This complete post may be read at the web address below

 

https://tinyurl.com/y9ru982u

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Nassar-MSU Scandal Puts Professional Licenses of 7 Under Scrutiny

Updated Jun 14, 12:30 PM; Posted Jun 14, 12:30 PM

By Julie Mack

M Live

http://www.mlive.com/news/index.ssf/2018/06/ nasser-msu_scandal_puts_profes.html

OR

https://tinyurl.com/y9grntgr

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Seven current and former health-care providers at Michigan State University are under investigation by the state Department of Licensing and Regulatory Affairs for their actions related to Larry Nassar, the former MSU doctor who molested patients.

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The seven — four physicians, two athletic trainers and a clinical psychologist — have been identified by Nassar victims as people alerted over the years about Nassar’s misconduct.

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Dr. William Strampel, an osteopathic physician who also was dean of MSU’s College of Osteopathic Medicine and Nassar’s former boss. Strampel is now facing criminal charges for failing to enforce rules set specifically for Nassar, including having a chaperone in the room during exams involving “sensitive areas” and getting patient permission before examining or treating those areas.

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Dr. Jeffrey Kovan, a osteopathic physician at MSU’s Sports Medicine Clinic. Kovan was the initial recipient of a complaint by Amanda Thomashow that she was molested by Nassar during a March 2014 appointment at the clinic. Kovan notified his supervisors of the complaint, although Thomashow told MSU Police she felt Kovan wasn’t taking it seriously, according to a police report.

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Dr. Douglas Dietzel, an osteopathic physician who supervised the MSU Sports Medical Clinic at the time of the 2014 complaint. An investigation by MSU’s Title IX office cleared Nassar in that incident.

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Dr. Brooke Lemmen, a former osteopathic physician at the Sports Medicine Clinic. She resigned in 2017 after Strampel reprimanded her for not telling MSU officials that she was aware Nassar stopped volunteering as a team doctor for USA Gymnastics in 2015 because of allegations of sexual misconduct. After Nassar was fired by MSU in 2016 and at his direction, Lemmen also removed boxes of documents from his office, according to a police report.

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Dr. Gary Stollak, a retired MSU clinic psychologist. One of Nassar’s early victims, Kyle Stephens, says that in 2004 when she was age 12, she told Stollak that she had been abused by Nassar over a six-year period. Instead of contacting authorities, she says, Stollak arranged a meeting between Nassar and her parents. Nassar denied the allegations and the parents forced Stephens to apologize. Stollak, who retired in 2010, has said he does not remember the Stephens case and he destroyed his patient records when he retired.

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Destiny Teachnor-Hauk, a MSU athletic trainer. Tiffany Thomas Lopez, a former MSU softball players who says she was molested by Nassar during treatments for sports injuries in 1999 and 2000, said she complained to Teachnor-Hauk that Nassar’s treatments seemed inappropriate.

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Lianna Hadden, a MSU athletic trainer. Lopez said she also complained to Hadden about Nassar’s treatments. Jennifer Rood Bedford, a former MSU volleyball player, says she told Hadden in 2003 that she was uncomfortable about Nassar’s treatments, although Bedford said she was not specific about her complaint.

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MSU colleagues initially defended Nassar, police investigation shows

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LARA does not comment on pending investigations, said LARA spokesman Pardeep Toor.

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The agency’s investigations are “strictly focused” on whether a license-holder has violated the Michigan public health code, he added.

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The complete article may be read at the URL above.

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Sincerely,
David Dillard
Temple University
(215) 204 – 4584
jwne@…

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Nassar-MSU Scandal Puts Professional Licenses of 7 Under Scrutiny

House: Alarming Findings in MSU, Nassar Inquiry

 

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THIS COMPLETE SOURCE MAY BE READ AT THE WEB ADDRESS BELOW

 

https://tinyurl.com/ycnxdal4

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House: Alarming Findings in MSU, Nassar Inquiry

Jonathan Oosting and Kim Kozlowski,

The Detroit News

Published 3:57 p.m. ET April 5, 2018

Updated 8:30 a.m. ET April 6, 2018

https://tinyurl.com/yaraeuow

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Lansing Larry Nassar was able to brazenly abuse women for decades because Michigan State University failed to properly pursue complaints, destroyed vital documents and allowed the disgraced doctor to exploit loopholes in university policies to avoid scrutiny, Michigan House lawmakers said Thursday.

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A months-long inquiry by the House into how MSU handled accusations of sexual assault by the former gymnastics doctor produced alarming findings that were forwarded to the attorney generals office for further investigation.

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While some of those findings remain under wraps because of an ongoing criminal investigation, bipartisan committee leaders disclosed several significant findings in a letter to House Speaker Tom Leonard, highlighting failures by MSU.

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Nassar seems to have spent decades developing his ability to abuse patients without detection by identifying and exploiting loopholes in the policies that governed his professional conduct and patient relationships, wrote lawmakers, describing their review of MSU documents and question responses.

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Medical records were never kept for many of Nassars treatments, they found. MSU did not have an adequate informed consent policy in place for much of the time he worked there, which Nassar methodically exploited, lawmakers said, and university policies did not require a chaperone to be in the room during sensitive examinations of minors.

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In some cases, MSU had destroyed patients medical records by the time they reported Nassar to university police, lawmakers said. While the destruction did not violate state law or university policy, such records may have proven useful to at least one of the survivors seeking justice against Nassar.

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MSU spokeswoman Emily Guerrant said following the inquirys release that MSU will be working with the House on its legislation and shares the joint concern of lawmakers who want to make sure the horrendous abuse that Larry Nassar executed cannot happen again.

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An attorney for the university answered dozens of questions from lawmakers, which they also released.

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Miller Canfield attorney Scott Eldridge told lawmakers that the university already has implemented a new privacy and chaperone policy. The universitys 10-year record retention policy exceeds the seven years required by state law, but the health team is conducting a global policy review, and there is potential that the minimum retention time will (be) addressed.

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The House findings are the result of an extensive inquiry by the Law and Justice Committee and the Appropriations Subcommittee on Higher Education. They requested Nassar-related information from MSU on Jan. 25 and received more than 1,500 pages of documents.

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The complete article may be read at the URL above.

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Sincerely,
David Dillard
Temple University
(215) 204 – 4584
jwne@…

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House: Alarming Findings in MSU, Nassar Inquiry

MSU to NCAA: Nassar Sexually Assaulted 25 Student-Athletes, but ‘no NCAA Rules Violations’

 

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THIS COMPLETE SOURCE MAY BE READ AT THE WEB ADDRESS BELOW

 

https://tinyurl.com/y8n2kda7

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MSU to NCAA: Nassar Sexually Assaulted 25 Student-Athletes,
but ‘no NCAA Rules Violations’

Matt Mencarini

Lansing State Journal

Published 8:17 p.m. ET May 2, 2018

Updated 12:24 p.m. ET May 3, 2018

Lansing State Journal

https://tinyurl.com/y9qrsjrb

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EAST LANSING – Larry Nassar sexually assaulted at least 25 MSU student-athletes, but there were no NCAA violations, the university has told the college athletics governing body.

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In January, during Nassar’s Ingham County sentencing hearing, the NCAA sent Michigan State University a letter regarding potential rules violations related to Nassar’s crimes.

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The university responded on March 22 in a letter from attorney Mike Glazier, of the law firm Bond, Schoeneck & King, PLLC, to the NCAA’s vice president of enforcement. Glazier listed the current ongoing investigations of the university, including those by the Michigan Attorney General’s Office, U.S. Congress and the U.S. Department of Education.

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(Read the letter at the bottom of this story.)

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“I trust that you will see that the University is in no way attempting to sidestep the issues facing it, and that if the University had any reason to believe the criminal conduct of Nassar also implicated NCAA rules violations, the University would accept responsibility in that area as well,” Glazier wrote in the letter, which MSU released on Wednesday.

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“However, after a thorough and analytic examination of NCAA legislation, and an application of the known facts associated with the Nassar matter to NCAA legislation, the University finds no NCAA rules violations.”

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Glazier said Nassar’s criminal conduct was “abhorrent and a violation of every standard of conduct expected of university of employees.”

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The letter recapped a meeting and phone calls involving MSU and NCAA officials that refined the issues the university needed to address in its response. It also stated that the university is committed to NCAA Bylaw 20.9.1.6, which covers the well-being of student athletes including their health and safety, but notes that bylaw is a guide and not subject to enforcement.

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The complete article may be read at the URL above.

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Sincerely,
David Dillard
Temple University
(215) 204 – 4584
jwne@…

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MSU to NCAA: Nassar Sexually Assaulted 25 Student-Athletes, but ‘no NCAA Rules Violations’

URL Shortening and Google and Alternatives

 

David P. Dillard
8:08 am   

THIS COMPLETE SOURCE MAY BE READ AT THE WEB ADDRESS BELOW
https://tinyurl.com/yb2yswav

 

URL Shortening and Google and Alternatives

Google URL Shortener

OR

Google Giveth and Then Google Taketh Away

Google URL Shortener

https://goo.gl/

Starting March 30, 2018, we will be turning down support for goo.gl URL shortener. From April 13, 2018 only existing users will be able to create short links on the goo.gl console. You will be able to view your analytics data and download your short link information in csv format for up to one year, until March 30, 2019, when we will discontinue goo.gl. Previously created links will continue to redirect to their intended destination. Please see this blog post for more details.

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Transitioning Google URL Shortener to Firebase Dynamic Links
Friday, March 30, 2018

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Posted by Michael Hermanto, Software Engineer, Firebase
We launched the Google URL Shortener back in 2009 as a way to help people more easily share links and measure traffic online. Since then, many popular URL shortening services have emerged and the ways people find content on the Internet have also changed dramatically, from primarily desktop webpages to apps, mobile devices, home assistants, and more.

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To refocus our efforts, we’re turning down support for goo.gl over the coming weeks and replacing it with Firebase Dynamic Links (FDL). FDLs are smart URLs that allow you to send existing and potential users to any location within an iOS, Android or web app. We’re excited to grow and improve the product going forward. While most features of goo.gl will eventually sunset, all existing links will continue to redirect to the intended destination.

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For consumers

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Starting April 13, 2018, anonymous users and users who have never created short links before today will not be able to create new short links via the goo.gl console. If you are looking to create new short links, we recommend you check out popular services like Bitly and Ow.ly as an alternative.

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If you have existing goo.gl short links, you can continue to use all features of goo.gl console for a period of one year, until March 30, 2019, when we will discontinue the console. You can manage all your short links and their analytics through the goo.gl console during this period.

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After March 30, 2019, all links will continue to redirect to the intended destination. Your existing short links will not be migrated to the Firebase console, however, you will be able to export your link information from the goo.gl console.

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Some alternatives to the Google URL Shortening Tool

The 9 Best URL Shorteners to Shorten Long Links

Automatically turn your long URLs into shorter, more shareable links

by Elise Moreau

Updated June 03, 2018

Lifewire

https://www.lifewire.com/shortening-long-links-3486603

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The 5 Best Alternatives to Google URL Shortener – Zapier

https://zapier.com/blog/best-url-shorteners/

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If you’ve ever relied on goo.gl to tighten up links for you, it’s time to start thinking about alternative URL shorteners. Google ended support for its Google URL Shortener at the end of March 2018 and is taking a year to fully phase out the tool.

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URL shorteners make sharing written-out links more manageable. Say you want to provide a link on a business card, in an advertisement, or in an email format where hyperlinking isn’t ideal. A shortened URL takes up less space and keeps your text tidy. For example, using goo.gl, you can convert
https://www.blog.google/products/maps/wheres-waldo-find-him-google-maps/
to https://goo.gl/rVBBtP. It’s easier to read and easier for someone to copy and paste or type.

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Some URL shorteners do little more than turn long links into short ones, while others let you customize the text of the new URLs, track click-through rates, and analyze other information about who’s clicking your links. Most URL shorteners have a free tier of service, but you often have to pay for added features, such as data and analysis. The five that made the cut for this list are easy to use and access, and each one stands out for one special reason, noted as “Best for” below.

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URL shortening – Wikipedia

https://en.wikipedia.org/wiki/URL_shortening

URL shortening is a technique on the World Wide Web in which a Uniform Resource Locator (URL) may be made substantially shorter and still direct to the required page. This is achieved by using a redirect which links to the web page that has a long URL. For example, the URL “http://example.com/assets/category_B/subcategory_C/Foo/” can be shortened to “https://example.com/Foo”, and the URL “http://example.com/about/index.html” can be shortened to “https://goo.gl/aO3Ssc”. Often the redirect domain name is shorter than the original one. A friendly URL may be desired for messaging technologies that limit the number of characters in a message (for example SMS), for reducing the amount of typing required if the reader is copying a URL from a print source, for making it easier for a person to remember, or for the intention of a permalink. In November 2009, the shortened links of the URL shortening service Bitly were accessed 2.1 billion times.[1]

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Other uses of URL shortening are to “beautify” a link, track clicks, or disguise the underlying address. Although disguising of the underlying address may be desired for legitimate business or personal reasons, it is open to abuse.[2] Some URL shortening service providers have found themselves on spam blacklists, because of the use of their redirect services by sites trying to bypass those very same blacklists. Some websites prevent short, redirected URLs from being posted.

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Contents

1 Purposes
2 Registering a short URL
3 Techniques
4 Expiry and time-limited services
5 History
6 Advantages
7 Shortcomings
7.1 Abuse
7.2 Linkrot
7.3 Transnational law
7.4 Blocking and banning
7.5 Advertising
7.6 Privacy and security
7.7 Additional layer of complexity
8 Services
9 See also
10 References
11 External links

The 6 Best URL Shorteners and How to Choose The Right One

https://tinyurl.com/jxrc4be

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Bitly

https://tinyurl.com/jxrc4be

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TinyURL

https://tinyurl.com/create.php

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Top 5 URL Shorteners (And 3 Honorable Mentions) Adweek

https://www.adweek.com/digital/top-5-url-shorteners-and-3-honorable-mentions/

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List of URL Shorteners

URL Shortening Services List

https://bit.do/list-of-url-shorteners.php

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The Ultimate List of The 11 Best URL Shortener Services

https://www.intelligenteconomist.com/url-shortener-services/

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Best URL Shorteners to Use in 2018 – Tech Advisor

https://www.techadvisor.co.uk

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5 Reasons You Should Stop Shortening URLs – Forbes

Forbes

Yael Grauer , CONTRIBUTOR

I write about technology, security, and online privacy.

https://www.forbes.com/sites/ygrauer/2016/04/20/
five-reasons-you-should-stop-shortening-urls/#1e24bd493f69

OR

https://tinyurl.com/yd7w9d9x

A recent paper by Cornell Tech researcher Vitaly Shmatikov and independent researcher Martin Georgiev demonstrated that shortening URLs can have serious privacy consequences. Because shortened URLs are so short, they are vulnerable to brute-force scanning, meaning that attackers can guess multiple shortened URLs and read all of the working ones. The researchers looked at Microsoft MSFT +0.74%
Microsoft
MSFT
$101.63$0.75(+0.74%)

As of 06/11/2018, 07:56am EDT

Ambient Tech That Actually Works: H&M Launches A Voice Activated Mirror
The World’s Largest Tech Companies 2018: Apple, Samsung Take Top Spots Again
OneDrive and Google GOOGL -0.12%
Google
GOOGL
$1132.38$-1.3(-0.12%)

As of 06/11/2018, 07:56am EDT

Google Accidentally ‘Confirms’ Expensive Pixel 3
Google Leak Reveals Pixel 3 Display Sizes
maps URLs shortened using bit.ly. They found that shortened URLs shared on a cloud service are effectively public. In the case of Microsoft OneDrive, they’re vulnerable to malware injection as well.

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Topics Discussed in This Article

Many people won’tor shouldn’tclick on shortened URLs

People who do click through might feel betrayed.

You have less control over your URL if you use a URL shortening service.

There are many other ways to get analytics.

Bonus: Long URLs no longer take up more characters on Twitter

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Top URL Shortener Sites You Should Use For Shrinking Long URL’s

https://www.shoutmeloud.com/5-sites-you-should-use-for-shortening-urls.html

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Google is shuttering its URL shortening service, goo.gl – The Verge

https://tinyurl.com/y9tc7qlr

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The Beginner’s Guide to URL Shorteners – Buffer Blog

https://blog.bufferapp.com/url-shorteners

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8 reasons why you should use URL shorteners

https://www.livechatinc.com/url-shortener/8-reasons-why-to-use-url-shortener/

Topics Covered in This Post

#1 Everyone prefers clean and short links

#2 Whoa, free URL customization ahead!

#3 Monitor your effectiveness with clicks tracking

#4 Go beyond number of clicks and see your traffic behavior.

#5 Keep all your shortened links and insight in one place

#6 Cut marketing costs by cutting number of characters

#7 Your social previews and thumbnails are safe

#8 SEO? URL shorteners take care of that too

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WEBBIB1718

http://tinyurl.com/yaevofzf

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Sincerely,

David Dillard

Temple University

(215) 204 – 4584

jwne@…

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URL Shortening and Google and Alternatives

DATABASE SEARCH RESULTS : DATABASE COMPARISONS : DATABASES: MEDICAL: Finding Database Content, Comparisons, Evaluations and the Nature of Content Shared in Selected Medical Databases from Database Search Results

 

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THIS COMPLETE SOURCE MAY BE READ AT THE WEB ADDRESS BELOW

 

https://tinyurl.com/yaroeqdy

 

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DATABASE SEARCH RESULTS :

DATABASE COMPARISONS :

DATABASES: MEDICAL:

Finding Database Content, Comparisons, Evaluations
and the Nature of Content Shared
in Selected Medical Databases from Database Search Results

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These links may help with this question.  I also believe that the value of
databases is not just determined by the content provided, but also by the
search features of the platform it is found on as finding content is as
important as the content being available in a database.  Search capabilities
are particularly important in the worlds of evidence based, systematic
reviews and the meta-analysis as the quality and thoroughness of search
results for projects involving these.  Expect many false drops in these
results, but there also seems to be a substantial collection of on topic
sources as well.  The first group of links compares Embase with
Pubmed and the second group adds Web of Science and Scopus to the mix.
There will also be comparisons of PubMed to Medline and Pubmed Central
which may be helpful to some users of this post. Methods sections of
publications that discuss specific topics may also provide clues to
comparative database usefulness in searches for the content shared in
those research studies.

Google Scholar
https://tinyurl.com/y8c37oaj

Content Sample

Optimal search strategies for detecting clinically sound prognostic studies in EMBASE: an analytic survey

NL Wilczynski, RB Haynes – Journal of the American Medical …, 2005 – academic.oup.com

… regression approaches to developing search strategies did not improve performance compared
with search … search strategies.17 We would welcome head-to-head comparisons of machine … other
approaches with our new “brute force” strategies in MEDLINE, EMBASE, or other …

Cited by 79 Related articles All 11 versions


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[HTML] Comparison of top-performing search strategies for detecting clinically sound treatment studies
and systematic reviews in MEDLINE and EMBASE

SSL Wong, NL Wilczynski… – Journal of the Medical …, 2006 – ncbi.nlm.nih.gov

… 2 present top-performing search strategies that allow for meaningful comparisons between
MEDLINE … and MEDLINE filters generally performed a little better than EMBASE filters. Considering
the unique content coverage and search terms available in MEDLINE and EMBASE …

Cited by 92 Related articles All 6 versions


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Should meta-analysts search Embase in addition to Medline?

M Sampson, NJ Barrowman, D Moher… – Journal of clinical …, 2003 – jclinepi.com

… We identified meta-analyses that searched Medline and Embase. A random-effects
weighted mean method was used to estimate the intervention effect in articles indexed
only in Embase compared with those indexed elsewhere …

Cited by 142 Related articles All 8 versions

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[HTML] EMBASE search strategies for identifying methodologically sound
diagnostic studies for use by clinicians and researchers

NL Wilczynski, RB Haynes – BMC medicine, 2005 – bmcmedicine.biomedcentral.com

… fail’ according to explicit criteria for scientific merit. Candidate search strategies were
run in EMBASE, the retrievals being compared with the hand search data. The
proposed search strategies were treated as “diagnostic tests …

Cited by 71 Related articles All 9 versions

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[HTML] Developing optimal search strategies for detecting
clinically sound treatment studies in EMBASE

SSL Wong, NL Wilczynski… – Journal of the Medical …, 2006 – ncbi.nlm.nih.gov

… Compared with the 3-term strategy with the best sensitivity, this represented an absolute increase
in … in indexing practices and thesaurus terms, and use of different search engines) make direct
comparisons of our top-performing treatment filters for EMBASE with those for …

Cited by 152 Related articles All 8 versions

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EMBASE search strategies achieved high sensitivity and specificity
for retrieving methodologically sound systematic reviews

NL Wilczynski, RB Haynes – Journal of clinical epidemiology, 2007 – jclinepi.com

… combinations. Candidate search strategies were run in EMBASE, the retrievals being
compared with the hand search data. The sensitivity, specificity, precision, and
accuracy of the search strategies were calculated. Results …

Cited by 84 Related articles All 8 versions

 

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[HTML] Developing optimal search strategies for detecting
clinically sound and relevant causation studies in EMBASE

RB Haynes, M Kastner… – BMC medical …, 2005 – bmcmedinformdecismak …

… Compared with the best sensitivity single-term strategy, “exp general aspects of disease”, the
combination strategy resulted in an absolute increase in both sensitivity (19 … Unfortunately, we
were only able to do limited comparisons between EMBASE and MEDLINE …

Cited by 44 Related articles All 8 versions

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Developing optimal search strategies for retrieving clinically relevant
qualitative studies in EMBASE

LA Walters, NL Wilczynski… – Qualitative Health …, 2006 – journals.sagepub.com

… We previously tested similar search strategies in MEDLINE, identifying 49,028 articles from
matching hand searches with downloaded data in MEDLINE, of which 366 (0.75%) were
qualitative, compared to 27,769 articles identified in EMBASE, of …

Cited by 61 Related articles All 6 versions

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Comparison of CINAHL, EMBASE, and MEDLINE databases for the nurse researcher

J Burnham, B Shearer – Medical Reference Services Quarterly, 1993 – Taylor & Francis

… Several studies have compared the coverage of EMBASE and MEDLINE for specific subject^.^-^
A study reported by Grfith, White, Drott, and Saye in 1988 focused on the coverage of six
databases, including MEDLINE and EMBASE, for the literature of medical behavioral …

Cited by 32 Related articles All 4 versions

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Accuracy of physician self-assessment compared
with observed measures of competence: a systematic review

DA Davis, PE Mazmanian, M Fordis, R Van Harrison… – Jama, 2006 – jamanetwork.com

ContextCore physician activities of lifelong learning, continuing medical education credit,
relicensure, specialty recertification, and clinical competence are.

Cited by 1599 Related articles All 17 versions

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[HTML] Optimal search strategies for detecting cost and economic studies in EMBASE

RJ McKinlay, NL Wilczynski… – BMC Health …, 2006 – bmchealthservres.biomedcentral …

… The best evidence currently available from research regarding both cost and economic
comparisons will continue to expand as this … search strategies were developed for economic and
cost studies, then run in the 55 EMBASE journals, the retrievals being compared with the …

Cited by 37 Related articles All 8 versions

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Nicotine dependence versus smoking prevalence: comparisons
among countries and categories of smokers.

KO Fagerström, M Kunze, R Schoberberger… – Tobacco …, 1996 – tobaccocontrol.bmj.com

… Nicotine dependence versus smoking prevalence: comparisons among countries and categories
of smokers … we con- ducted a search of the electronic database EMBASE (formerly Excerpta … the
quitting percentage was higher among less dependent smokers compared with the …

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Identifying randomized controlled trials of cognitive therapy for depression:
comparing the efficiency of Embase, Medline and PsycINFO bibliographic databases

RJD Watson, PH Richardson – Psychology and Psychotherapy …, 1999 – Wiley Online Library

… decrease. It is possible that the low sensitivity of PsycINFO searches, compared with
Embase and Medline, may be offset by PsycINFO’s wider coverage of psychiatric and
psycho- logical journals than either Embase or Medline. To …

Cited by 52 Related articles All 5 versions

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Cochrane reviews compared with industry supported meta-analyses
and other meta-analyses of the same drugs: systematic review

AW Jørgensen, J Hilden, PC Gøtzsche – Bmj, 2006 – bmj.com

… reviews in the Cochrane Database of Systematic Reviews 2003, issue 1 for drug comparisons …
When we found no match in PubMed, we searched Embase (WebSPIRS 5) (1980 to … recommended
only with reservations.3 As our data were paired, we compared quantitative data …

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The comprehensiveness of Medline and Embase computer searches

J Kleijnen, P Knipschild – Pharmaceutisch weekblad, 1992 – Springer

… Thus, all in all, the Embase search and consequent checking of references yielded 42 … For our
three comparisons, and for the comparisons made by Hofmans [6] (the exhaustive … The yield of
Medline searches as compared with comprehensive reviews or other registers was 17 …

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Google Books
https://tinyurl.com/y8698e24

CONTENT SAMPLE

Drug Information: A Guide to Current Resources – Page 395

https://books.google.com/books?isbn=0810833212

Bonnie Snow – 1999 – ‎Preview – ‎More editions

Another notable difference between MEDLINE subheadings and EMBASE link terms is that
the latter offer several extras for … Reference (6.l0), Drug Facts and Comparisons (6.2),
or MEDLINE may sometimes differ from that used in EMBASE.

Anaemia Management in Chronic Kidney Disease: National Clinical …

https://books.google.com/books?isbn=1860162932

National Collaborating Centre for Chronic Conditions (Great Britain) – 2006 – ‎Preview – ‎More editions

Embase 1980–2005 Cochrane 1800–2005 Cinahl 1982–2005 BNI 1985–2005 PAT2 Is the effectiveness
of anaemia … Medline 1966–2005 correcting anaemia with epoetin alfa compared to RCTs
and comparative Embase 1980–2005 …

The Evidence Base of Clinical Diagnosis: Theory and Methods of …

https://books.google.com/books?isbn=1444360639

  1. André Knottnerus, ‎Frank Buntinx – 2011 – ‎Preview– ‎More editions

Compared to MEDLINE Additional publications on nursing and allied health subjects
More document types as sources More … Name EMBASE and EMBASE ALERT
Excerpta Medica Database Producer Elsevier Science bv, Amsterdam, the …

Chronic Kidney Disease: National Clinical Guideline for Early … – Page 3

https://books.google.com/books?isbn=1860163408

National Collaborating Centre for Chronic Conditions (Great Britain) – 2008 – ‎Preview

Systematic reviews, RCTs Medline 1966–2008 Embase 1980–2008 Cochrane 1800–2008
Cinahl 1982–2008 LIPID 1 In … fibrates, fish oils) decrease cardiovascular disease risk
and all cause mortality compared with placebo or each other?


Google 
https://tinyurl.com/y8cqbxz8

Google Domain Limited Search (PUBMED)
https://tinyurl.com/y8dfefzx

CONTENT SAMPLE

Embase vs. PubMed & MEDLINE – Embase Guide | Guía de Embase …

https://library.fiu.edu › … › Embase Guide | Guía de Embase

ADDITIONAL COMPARISONSEmbase … PubMedMEDLINE, and Embase all let you
access MEDLINE, the U.S. National Library of … using the “‘Find It @ FIU” icons/links
or by going to the publishers’ websites using the “View Full Text” tabs.

Has Embase replaced MEDLINE since coverage expansion?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886505/

by MT Lam – ‎2018

Apr 1, 2018 – We hypothesized that studies that used Embase but not MEDLINE ….
time (3 pairs of possible states compared over 2 different intervals of time, …

Are men difficult to find? Identifying male-specific studies in MEDLINE …

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120011/

by F Stewart – ‎2014 – ‎Cited by 8 – ‎Related articles

Jul 18, 2014 – The proposed MEDLINE and Embase filters achieved high sensitivity
and a …. terms and the results were compared to the best performing individual
candidate term. … [SO] NOT ((women not men) OR (female not male)).tw …..
University of York Available from URL: https://sites.google.com/a/york.ac.uk/issg- …

Find Duplicates among the PubMed, EMBASE, and Cochrane Library …

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748039/

by X Qi – ‎2013 – ‎Cited by 49 – ‎Related articles

Aug 20, 2013 – For type-I duplicates, reference items were further compared between
index and …. 2) The volume, issue, and page were missing in EMBASE.

central – Cochrane Library

www.cochranelibrary.com/about/central-landing-page.html

Unique content (i.e. records not already identified in MEDLINE, etc.) …
retrieved from MEDLINEEmbase, and other databases are merged is described here.

Central Creation Details – Cochrane Library

www.cochranelibrary.com/help/central-creation-details.html

Preview the new Cochrane Library website … Metaxis, on behalf of Cochrane, identify
all the records in PubMed that are indexed … Identifying Embase RCTs and CCTs for
inclusion in CENTRAL …. ((evaluated or evaluate or evaluating or assessed or assess)
and (compare or compared or comparing or comparison)).ab.

Glomerular disease search filters for Pubmed, Ovid Medline, and …

https://bmcmedinformdecismak.biomedcentral.com/articles/10…/1472-6947-12-49

by AM Hildebrand – ‎2012 – ‎Cited by 10 – ‎Related articles

Glomerular disease search filters for Pubmed, Ovid Medline, and Embase: a development
and validation study. Ainslie M Hildebrand†,; Arthur V Iansavichus†, …

Search strategies to identify reports on “off-label” drug use in EMBASE …

https://bmcmedresmethodol.biomedcentral.com/articles/10.1186/1471-2288-12-190

by B Mesgarpour – ‎2012 – ‎Cited by 8 – ‎Related articles

Off-label useInformation retrievalEMBASEMEDLINESensitivity … We compared the
retrieval performance of each candidate term and combination of ….
((inappropriate us* and indication) not (antibiotic* or antimicrobial)).af. …. has also failed to
provide author’s name and had a typo error in start page (202 instead of 201).

High-performance information search filters for acute kidney injury …

https://academic.oup.com/ndt/article/29/4/823/1931288

by AM Hildebrand – ‎2014 – ‎Cited by 11 – ‎Related articles

Jan 20, 2014 – PubMed, Ovid Medline and Embase can be filtered for articles …. 26],
systematic reviews [27–31], website glossaries and clinician and librarian opinions. ….
with and without the validated filters, compared with the reference standard, …. or dialysis)).mp
OR exp Acute Kidney Injury/ OR ((kidney or renal) adj …

[PDF]Appendix 1. Detailed search strategies of PubMed, Scopus, EMBASE …

download.lww.com/…/A/CCM_42_2_2013_07_25_MILLER_204823_SDC1.pdf

Page 1 … Detailed search strategies of PubMed, Scopus, EMBASE, and Web of Science …
antithrombins) AND TITLE(smoke)) … P < 0.05 compared to controls.

Google Domain Limited Search (SCIENCEDIRECT)
https://tinyurl.com/yaxwpb9s

PUBMED
https://tinyurl.com/ybbenyf8

PUBMED Central
https://tinyurl.com/yd3ljkkj

TRIP
https://tinyurl.com/y9oorh59

Here is a broader search for comparisons of more databases.

Google Scholar
https://tinyurl.com/y8tplpfo

Google Books
https://tinyurl.com/y7s4ddxz

PUBMED
https://tinyurl.com/yd27carc

TRIP
https://tinyurl.com/y9oatynj

Google
https://tinyurl.com/ydhlcrl4

Google Domain Limited Web Search (PUBMED)
https://tinyurl.com/y8h5e4s7

PUBMED CENTRAL
https://tinyurl.com/y74uc53m

CONTENT SAMPLE

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    OR best OR effective OR (“search results” AND quality))
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Select item 45936171.

Accessing Biomedical Literature in the Current Information Landscape

Ritu Khare, Robert Leaman, Zhiyong Lu

Methods Mol Biol. Author manuscript; available in PMC 2015 Oct 5.

Published in final edited form as: Methods Mol Biol. 2014; 1159: 11–31.
doi: 10.1007/978-1-4939-0709-0_2

PMCID:PMC4593617

ArticlePubReaderPDF–224KCitation

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Multidisciplinary Bibliographic Databases

Armen Yuri Gasparyan, Lilit Ayvazyan, George D. Kitas

J Korean Med Sci. 2013 Sep; 28(9): 1270–1275. Published online 2013 Aug 28.
doi: 10.3346/jkms.2013.28.9.1270

PMCID:PMC3763098

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ON-LINE BIOMEDICAL DATABASES–THE BEST SOURCE FOR QUICK
SEARCH OF THE SCIENTIFIC INFORMATION IN THE BIOMEDICINE

Izet Masic, Katarina Milinovic

Acta Inform Med. 2012 Jun; 20(2): 72–84. doi: 10.5455/aim.2012.20.72-84

PMCID:PMC3544328

ArticlePubReaderPDF–1.8MCitation

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Optimal database combinations for literature searches in systematic reviews:
a prospective exploratory study

Wichor M. Bramer, Melissa L. Rethlefsen, Jos Kleijnen, Oscar H. Franco

Syst Rev. 2017; 6: 245. Published online 2017 Dec 6. doi: 10.1186/s13643-017-0644-y

PMCID:PMC5718002

ArticlePubReaderPDF–911KCitation

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Biomedical research platforms and their influence
on article submissions and journal rankings: An update.

Giuseppe Lippi, Emmanuel J Favaloro, Ana-Maria Simundic

Biochem Med (Zagreb) 2012 Feb; 22(1): 7–14. Published online 2012 Feb 15.

PMCID:PMC4062318

ArticlePubReaderPDF–132KCitation

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PubFocus: semantic MEDLINE/PubMed citations analytics
through integration of controlled biomedical dictionaries and ranking algorithm

Maksim V Plikus, Zina Zhang, Cheng-Ming Chuong

BMC Bioinformatics. 2006; 7: 424. Published online 2006 Oct 2.
doi: 10.1186/1471-2105-7-424

PMCID:PMC1618408

ArticlePubReaderPDF–2.4MCitation

Select item 51204117.

Optimizing literature search in systematic reviews – are MEDLINE
EMBASE
 and CENTRAL enough for identifying effect studies
within the area of musculoskeletal disorders?

Thomas Aagaard, Hans Lund, Carsten Juhl

BMC Med Res Methodol. 2016; 16: 161. Published online 2016 Nov 22.
doi: 10.1186/s12874-016-0264-6

PMCID:PMC5120411

ArticlePubReaderPDF–566KCitation

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Video-Assisted Thoracoscopic Sympathectomy for Palmar Hyperhidrosis:
A Meta-Analysis of Randomized Controlled Trials

Wenxiong Zhang, Dongliang Yu, Han Jiang, Jianjun Xu, Yiping Wei

PLoS One. 2016; 11(5): e0155184. Published online 2016 May 17.
doi: 10.1371/journal.pone.0155184

PMCID:PMC4871499

ArticlePubReaderPDF–5.0MCitation

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A systematic review and meta-analysis of T2, T3 or T4,
to evaluate the best denervation level for palmar hyperhidrosis

Wenxiong Zhang, Dongliang Yu, Yiping Wei, Jianjun Xu, Xiaoqiang Zhang

Sci Rep. 2017; 7: 129. Published online 2017 Mar 9. doi: 10.1038/s41598-017-00169-w

PMCID:PMC5427933

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Gefitinib provides similar effectiveness and improved safety than erlotinib
for advanced non-small cell lung cancer: A meta-analysis

Wenxiong Zhang, Yiping Wei, Dongliang Yu, Jianjun Xu, Jinhua Peng

Medicine (Baltimore) 2018 Apr; 97(16): e0460. Published online 2018 Apr 20.
doi: 10.1097/MD.0000000000010460

PMCID:PMC5916648

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Comparing the coverage, recall, and precision of searches for 120 systematic reviews
in EmbaseMEDLINE, and Google Scholar: a prospective study

Wichor M. Bramer, Dean Giustini, Bianca M. R. Kramer

Syst Rev. 2016; 5: 39. Published online 2016 Mar 1. doi: 10.1186/s13643-016-0215-7

PMCID:PMC4772334

ArticlePubReaderPDF–699KCitation

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Information sources for obesity prevention policy research: a review of systematic reviews

Rosie Hanneke, Sabrina K. Young

Syst Rev. 2017; 6: 156. Published online 2017 Aug 8. doi: 10.1186/s13643-017-0543-2

PMCID:PMC5549286

ArticlePubReaderPDF–668KCitation

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Thoracotomy is better than thoracoscopic lobectomy in the lymph node dissection
of lung cancer: a systematic review and meta-analysis

Wenxiong Zhang, Yiping Wei, Han Jiang, Jianjun Xu, Dongliang Yu

World J Surg Oncol. 2016; 14: 290. Published online 2016 Nov 17.
doi: 10.1186/s12957-016-1038-7

PMCID:PMC5114806

ArticlePubReaderPDF–1.8MCitation

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Tips and tricks for using the internet for professional purposes

Hasan Huseyin Ceylan, Nurdan Güngören, Fatih Küçükdurmaz

EFORT Open Rev. 2017 May; 2(5): 126–134. Published online 2017 May 11.
doi: 10.1302/2058-5241.2.160066

PMCID:PMC5467674

ArticlePubReaderPDF–1.2MCitation

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OvidSP Medline-to-PubMed search filter translation: a methodology
for extending search filter range to include PubMed‘s unique content

Raechel A Damarell, Jennifer J Tieman, Ruth M Sladek

BMC Med Res Methodol. 2013; 13: 86. Published online 2013 Jul 2.
doi: 10.1186/1471-2288-13-86

PMCID:PMC3700762

ArticlePubReaderPDF–230KCitation

Select item 363033916.

Citation Analysis of the Korean Journal of Urology
From Web of ScienceScopus, Korean Medical Citation Index,
KoreaMed Synapse, and Google Scholar

Sun Huh

Korean J Urol. 2013 Apr; 54(4): 220–228. Published online 2013 Apr 16.
doi: 10.4111/kju.2013.54.4.220

PMCID:PMC3630339

ArticlePubReaderPDF–443KCitation

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Psychological distress related to smoking cessation
in patients with acute myocardial infarction

Thyego Mychell Moreira-Santos, Irma Godoy, Ilda de Godoy

J Bras Pneumol. 2016 Jan-Feb; 42(1): 61–67.
doi: 10.1590/S1806-37562016000000101

PMCID:PMC4805389

ArticlePubReaderPDF–287KCitation

Select item 256885618.

Defrosting the Digital Library:
Bibliographic Tools for the Next Generation Web

Duncan Hull, Steve R. Pettifer, Douglas B. Kell

PLoS Comput Biol. 2008 Oct; 4(10): e1000204.
Published online 2008 Oct 31. doi: 10.1371/journal.pcbi.1000204

PMCID:PMC2568856

ArticlePubReaderPDF–599KCitation

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Gaps in affiliation indexing in Scopus and PubMed

Cynthia M. Schmidt, Roxanne Cox, Alissa V. Fial,
Teresa L. Hartman, Martha L. Magee

J Med Libr Assoc. 2016 Apr; 104(2): 138–142.
doi: 10.3163/1536-5050.104.2.008

PMCID:PMC4816483

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Public Funding and Open Access to Research:
A Review of Canadian Multiple Sclerosis Research

Caitlin Bakker, Carol Stephenson, Erin Stephenson,
Debbie Chaves

J Med Internet Res. 2017 Feb; 19(2): e52.
Published online 2017 Feb 27. doi: 10.2196/jmir.6250

PMCID:PMC5348618

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http://tinyurl.com/yaevofzf

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Sincerely,
David Dillard
Temple University
(215) 204 – 4584
jwne@…

RESEARCH GUIDE DIRECTORY
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DATABASE SEARCH RESULTS : DATABASE COMPARISONS : DATABASES: MEDICAL: Finding Database Content, Comparisons, Evaluations and the Nature of Content Shared in Selected Medical Databases from Database Search Results

Michigan States Larry Nassar Fallout Has Begun

 

*

THIS COMPLETE SOURCE MAY BE READ AT THE WEB ADDRESS BELOW

*

Michigan States Larry Nassar Fallout Has Begun

The university has agreed to pay $500 million to more than 300 victims.

By Jen Kirbyjen

Updated May 16, 2018, 5:21pm EDT

Vox

https://www.vox.com/policy-and-politics/2018/1/30/16934634/
michigan-state-larry-nassar-settlement-investigations

.

A shorter URL for the above link:

.

https://tinyurl.com/yckva7ap

.

.

Michigan State University said May 16 it had reached a $500 million settlement with more than 300 women and girls who alleged Larry Nassar, the former USA Gymnastics and Michigan State University doctor, sexually abused them.

.

The university will pay out $425 million, and set aside another $75 million for survivors who may come forward in the future. The payout far exceeds the $109 million Penn State paid to its more than 30 victims in the case of former assistant football coach Jerry Sandusky, who was convicted of molesting young boys in 2012.

.

The settlement should resolve the scores of lawsuits against MSU, and it represents the harshest consequences yet for a university that has grappled with a slow burning crisis for months. MSU president Lou Anna Simon resigned in January, hours after Nassars sentencing. William Strampel, the former dean of MSUs College of Osteopathic Medicine and Nassars former boss, was charged with crimes related to sexual misconduct and abuse of power. The MSU athletic director also retired.

.

The Department of Education has opened a formal investigation into the university. So has the NCAA. Michigan Attorney General Bill Schuette embarked on a full review of the Nassar case and the failures of MSU, appointing a special prosecutor to lead the probe.

.

Families and onlookers have demanded that the university, as well as USA Gymnastics, reckon with its role in the scandal and explain how a doctor accused of molesting about 300 women and girls did not face real consequences for decades.

.

That silence enabled Nassar to become perhaps the worst known sexual predator in American sports history.

.

At Nassars sentencing hearing, 15-year-old Emma Ann Miller told the court Nassar had molested her in August 2016 at MSU. The university suspended him about a week after, she said, and she offered a chilling thought: Im possibly the last child he will ever assault.

.

Her mother, Miller added, was still getting bills from MSU sports medicine bills, she said, for appointments where I was sexually assaulted.

.

Additional Topics Covered in This Article

Women reported Nassar to MSU representatives as early as the 1990s

A 2014 Title IX investigation into Nassar raised red flags

MSU will pay out $500 million to Nassar victims

Multiple investigations into MSU are underway

Nassar has sparked broader concerns about MSUs handling of sexual assault cases

What comes next?

.

.

The complete article may be read at the URL above.

.

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Sincerely,
David Dillard
Temple University
(215) 204 – 4584
jwne@…

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Michigan States Larry Nassar Fallout Has Begun

MEDICAL: DISEASES : PHYSICAL EXERCISE AND FITNESS : CHILDREN: A Teen’s Muscle Soreness Turned Out to Be This Life-Threatening Condition

 

*

THIS COMPLETE SOURCE MAY BE READ AT THE WEB ADDRESS BELOW

https://tinyurl.com/ybzubdfh

*

MEDICAL: DISEASES :

PHYSICAL EXERCISE AND FITNESS :

CHILDREN:

A Teen’s Muscle Soreness Turned Out to Be This Life-Threatening Condition

*

*

A Teen’s Muscle Soreness Turned Out to Be This Life-Threatening Condition

By Rachael Rettner, Senior Writer

June 4, 2018 05:22pm ET

https://www.livescience.com/62738-teen-muscle-soreness-rhabdomyolysis.html

*

*

A Texas teen who felt extremely sore after a hard gym workout turned out to have a rare and potentially life-threatening condition called rhabdomyolysis. But how do you tell the difference between run-of-the-mill soreness and rhabdomyolysis?

.

The teen, Jared Shamburger, had recently signed up for a gym membership with his family, according to local news outlet KTRK. His older brother and dad had been weightlifting for years, and Shamburger wanted to “catch up” with them. “I have to go hard fast,” Shamburger, who is 17, told KTRK.

.

But after a 90-minute weightlifting session, Shamburger said he felt particularly sore. “Everything hurt. It hurt to the touch. It was swollen,” he said.

.

When the teen’s soreness and swelling didn’t go away, his mom, Judy Shamburger, looked up his symptoms online, and realized her son might have rhabdomyolysis. Her suspicion was right. The teen was diagnosed with the condition, sometimes referred to as “rhabdo,” and hospitalized for five days, KTRK reported.

*

snip

*

Shamburger is expected to make a full recovery, KTRK reported.

*

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Rhabdomyolysis – Wikipedia

https://en.wikipedia.org/wiki/Rhabdomyolysis

Rhabdomyolysis is a condition in which damaged skeletal muscle breaks down rapidly.[3] Symptoms may include muscle pains, weakness, vomiting, and confusion.[3][4] There may be tea-colored urine or an irregular heartbeat.[3] Some of the muscle breakdown products, such as the protein myoglobin, are harmful to the kidneys and may lead to kidney failure.[3]

The muscle damage is most often the result of a crush injury, strenuous exercise, medications, or drug abuse.[3] Other causes include infections, electrical injury, heat stroke, prolonged immobilization, lack of blood flow to a limb, or snake bites.[3] Some people have inherited muscle conditions that increase the risk of rhabdomyolysis.[3] The diagnosis is supported by a urine test strip which is positive for “blood” but the urine contains no red blood cells when examined with a microscope.[3] Blood tests show a creatine kinase greater than 1,000 U/L, with severe disease being above 5,000 U/L.[5]

The mainstay of treatment is large quantities of intravenous fluids.[3] Other treatments may include dialysis or hemofiltration in more severe cases.[4][6] Once urine output is established sodium bicarbonate and mannitol are commonly used but they are poorly supported by the evidence.[3][4] Outcomes are generally good if treated early.[3] Complications may include high blood potassium, low blood calcium, disseminated intravascular coagulation, and compartment syndrome.[3]

Rhabdomyolysis occurs in about 26,000 people a year in the United States.[3] While the condition has been commented on throughout history, the first modern description was following an earthquake in 1908.[7] Important discoveries as to its mechanism were made during the Blitz of London in 1941.[7] It is a significant problem for those injured in earthquakes and relief efforts for such disasters often include medical teams equipped to treat survivors with rhabdomyolysis.[7]

Contents

1 Signs and symptoms
2 Causes
2.1 Genetic predisposition
3 Mechanism
4 Diagnosis
4.1 General investigations
4.2 Complications
4.3 Underlying disorders
5 Treatment
5.1 Electrolytes
5.2 Acute kidney impairment
5.3 Other complications
6 Prognosis
7 Epidemiology
8 History
9 Etymology and pronunciation
10 Other animals
11 References
12 External links

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Rhabdomyolysis

Medline Plus

https://medlineplus.gov/ency/article/000473.htm

Rhabdomyolysis
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Rhabdomyolysis is the breakdown of muscle tissue that leads to the release of muscle fiber contents into the blood. These substances are harmful to the kidney and often cause kidney damage.
Causes

When muscle is damaged, a protein called myoglobin is released into the bloodstream. It is then filtered out of the body by the kidneys. Myoglobin breaks down into substances that can damage kidney cells.

Rhabdomyolysis may be caused by injury or any other condition that damages skeletal muscle.

Problems that may lead to this disease include:

Trauma or crush injuries
Use of drugs such as cocaine, amphetamines, statins, heroin, or PCP
Genetic muscle diseases
Extremes of body temperature
Ischemia or death of muscle tissue
Low phosphate levels
Seizures or muscle tremors
Severe exertion, such as marathon running or calisthenics
Lengthy surgical procedures
Severe dehydration

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Symptoms

Symptoms may include:

Dark, red, or cola-colored urine
Decreased urine output
General weakness
Muscle stiffness or aching (myalgia)
Muscle tenderness
Weakness of the affected muscles

Other symptoms that may occur with this disease:

Fatigue
Joint pain
Seizures
Weight gain (unintentional)

Exams and Tests

A physical exam will show tender or damaged skeletal muscles.

The following tests may be done:

Creatine kinase (CK) level
Serum calcium
Serum myoglobin
Serum potassium
Urinalysis
Urine myoglobin test

This disease may also affect the results of the following tests:

CK isoenzymes
Serum creatinine
Urine creatinine

Treatment

You will need to get fluids containing bicarbonate to help prevent kidney damage. You may need to get fluids through a vein (IV). Some people may need kidney dialysis.

Your health care provider may prescribe medicines including diuretics and bicarbonate (if there is enough urine output).

Hyperkalemia and low blood calcium levels (hypocalcemia) should be treated right away. Kidney failure should also be treated.
Outlook (Prognosis)

The outcome depends on the amount of kidney damage. Acute kidney failure occurs in many people. Getting treated soon after rhabdomyolysis will reduce the risk of permanent kidney damage.

People with milder cases may return to their normal activities within a few weeks to a month. However, some people continue to have problems with fatigue and muscle pain.
Possible Complications

Complications may include:

Acute tubular necrosis
Acute renal failure
Harmful chemical imbalances in the blood
Shock (low blood pressure)

When to Contact a Medical Professional

Call your provider if you have symptoms of rhabdomyolysis.
Prevention

Rhabdomyolysis can be avoided by:

Drinking plenty of fluids after strenuous exercise.
Removing extra clothes and immersing the body in cold water in case of heat stroke.

Images

Male urinary systemMale urinary system

References

O’Connor FG, Deuster PA. Rhabdomyolysis. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 113.

Parekh R. Rhabdomyolysis. In: Walls RM, Hockberger RS, Gausche-Hill M, eds. Rosen’s Emergency Medicine: Concepts and Clinical Practice. 9th ed. Philadelphia, PA: Elsevier; 2018:chap 119.

Uduman J, Singasani R. Rhabdomyolysis. In: Ferri FF, ed. Ferri’s Clinical Advisor 2018. Philadelphia, PA: Elsevier; 2018:1122-1124.
Review Date 8/1/2017

Updated by: Walead Latif, MD, nephrologist and Clinical Associate Professor, Rutgers Medical School, Newark, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC’s accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.’s editorial policy, editorial process and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (www.hon.ch).

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only — they do not constitute endorsements of those other sites. Copyright 1997-2018, A.D.A.M., Inc. Duplication for commercial use must be authorized in writing by ADAM Health Solutions.

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Rhabdomyolysis

PUBMED Health

https://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0024696/

Rhabdomyolysis

Rhabdomyolysis is a condition in which damaged skeletal muscle tissue breaks down rapidly. Breakdown products of damaged muscle cells are released into the bloodstream. Some of these, such as the protein myoglobin, are harmful to the kidneys and may lead to kidney failure.

PubMed Health Glossary
(Source: Wikipedia)

About Rhabdomyolysis

Rhabdomyolysis is an extremely rare but serious side effect where muscle tissue gradually breaks down in certain muscles. This can lead to permanent paralysis, and the breakdown products can cause serious kidney damage.

In studies, rhabdomyolysis was found to occur in 1 out of 10,000 people who took statins for longer periods of time.

Signs of this side effect include muscle ache and dark-colored urine, so it is important to seek medical advice if you have these symptoms. Institute for Quality and Efficiency in Health Care (IQWiG)

ults: 1 to 20 of 60

Is continuous renal replacement therapy beneficial for people with rhabdomyolysis?

Rhabdomyolysis is a potentially life-threatening condition where damaged muscle tissue breaks down quickly, and products of damaged muscle cells are released into the bloodstream. Of these products, a protein called myoglobin is harmful to kidney health and can lead to acute kidney injury. There is some evidence to suggest that continuous renal replacement therapy (CRRT) may provide benefits for people with rhabdomyolysis.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: June 15, 2014

Rhabdomyolysis in bariatric surgery: a systematic review

BACKGROUND: Rhabdomyolysis (RML) is a rare complication of bariatric surgery. A systematic review was performed to identify risk factors and patient outcomes in morbidly obese patients undergoing bariatric surgery who develop RML.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2013

Prevention of kidney injury following rhabdomyolysis: a systematic review

OBJECTIVE: To conduct a systematic literature review to evaluate evidence-based recommendations for the prevention of rhabdomyolysis-associated acute renal failure (ARF).

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2013

Statin-induced rhabdomyolysis: a comprehensive review of case reports

PURPOSE: To identify case reports of statin-induced rhabdomyolysis and summarize common predisposing factors, symptoms, diagnostic findings, functional outcomes, characteristics, treatment, and rehabilitation.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2014

Utility of urine myoglobin for the prediction of acute renal failure in patients with suspected rhabdomyolysis: a systematic review

This review concluded that there was inadequate evidence to evaluate use of urine myoglobin as a predictor of acute renal failure in patients with suspected rhabdomyolysis. There were limitations in the review and included studies, but the overall conclusion reflected the evidence presented.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2009

Systematic review and meta-analysis of clinically relevant adverse events from HMG CoA reductase inhibitor trials worldwide from 1982 to present

PURPOSE: Our objective was to determine the association of clinically relevant adverse events from a systematic review and meta-analysis of statin randomized controlled trials (RCT).

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2007

Statin Use for the Prevention of Cardiovascular Disease in Adults: A Systematic Review for the U.S. Preventive Services Task Force [Internet]

Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in the United States but is potentially preventable with statin therapy. The U.S. Preventive Services (USPSTF) commissioned this review to inform the development of new recommendations on use of statin therapy for prevention of CVD in adults.

Evidence Syntheses – Agency for Healthcare Research and Quality (US).
Version: November 2016
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Efficacy of statins for primary prevention in people at low cardiovascular risk: a meta-analysis

The review concluded that both low- and high-potency statins were efficacious in preventing death and cardiovascular-related morbidity in people at low risk of cardiovascular events, although the number needed to treat to prevent one adverse outcome was relatively high for any statin. The authors’ conclusions reflect the evidence available and appear likely to be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2011

Adverse events associated with individual statin treatments for cardiovascular disease: an indirect comparison meta-analysis

The use of statin therapy for cardiovascular disease was associated with a relatively low risk of adverse events. High risk of bias within the studies, high clinical and methodological heterogeneity between the studies, and a discrepancy between the initial outcomes stated and those actually reported suggest that the authors’ conclusions and recommendations may not be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2012

Intensive statin therapy in acute coronary syndromes and stable coronary heart disease: a comparative meta-analysis of randomised controlled trials

This review concluded that intensive-dose statin therapy reduced all-cause mortality in patients with recent acute coronary syndrome but not in patients with stable coronary heart disease, compared with moderate-dose statin therapy. The review was well-conducted and these conclusions are likely to be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2007

Lipid Modification: Cardiovascular Risk Assessment and the Modification of Blood Lipids for the Primary and Secondary Prevention of Cardiovascular Disease

This guideline updates for primary prevention, the NICE technology appraisal, Statins for the prevention of cardiovascular events (TA94, 2007) and reviews and updates the recommendations made in the NICE guideline Lipid Modification (CG67, 2008) for primary and secondary prevention of cardiovascular disease (CVD). The scope for this guideline was limited to the identification and assessment of CVD risk and to the assessment and modification of lipids in people at risk of CVD, or people with known CVD. The guideline development group wishes to make clear that lipid modification should take place as part of a programme of risk reduction which also include attention to the management of all other known CVD risk factors.

NICE Clinical Guidelines – National Clinical Guideline Centre (UK).
Version: July 2014
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Aerobic training for McArdle disease

McArdle disease is a rare disease of muscle metabolism. Affected people cannot use a starch-like substance called glycogen which is stored in muscle and used for energy at the beginning of activity and during strenuous exercise. The effects of the condition are fatigue and cramping within a few minutes of starting an activity, which can potentially lead to acute muscle damage. After about seven or eight minutes of exercise the muscle can start to use alternative sources of energy from fats and sugars supplied from the liver and so the symptoms ease. This phenomenon is called the ‘second wind’. In healthy people, aerobic training is known to improve the ability of muscle to burn fats for energy during exercise. In theory then, aerobic training could be beneficial to people with McArdle disease, as their muscles might be trained to use fats earlier and more efficiently during exercise. The purpose of this review was to identify any randomised controlled trials of aerobic training and assess its effects in people with McArdle disease. There were no randomised controlled trials of aerobic training in people with McArdle disease. There were, however, three small uncontrolled studies (the largest included nine participants). The studies showed that it is possible for people with McArdle disease to undergo exercise training and there were no harmful effects. Whether or not training is beneficial for people with McArdle disease needs further investigation, with randomised controlled trials including larger numbers of people with the condition.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: December 7, 2011

Statins for acute ischemic stroke

Stroke is a major public health problem than can cause death and severe disability. A limited number of drugs are available for treating patients with stroke. Statins, a group of drugs commonly used to reduce cholesterol levels, are known to be safe and effective when given to patients with an acute heart attack. Therefore, they may also be beneficial in patients with acute stroke. We identified eight relevant trials of statins in acute stroke involving 625 participants. Unfortunately, insufficient information was available to establish whether statins are safe and beneficial for patients with acute ischemic stroke

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: August 10, 2011

Drug Class Review: HMG-CoA Reductase Inhibitors (Statins) and Fixed-dose Combination Products Containing a Statin: Final Report Update 5 [Internet]

In the United States, coronary heart disease and cardiovascular disease account for nearly 40% of all deaths each year. Coronary heart disease continues to be the leading cause of mortality and a significant cause of morbidity among North Americans. In 2006, coronary heart disease claimed 607 000 lives, translating into about 1 out of every 5 deaths in the United States. High levels of cholesterol, or hypercholesterolemia, are an important risk factor for coronary heart disease. The 3-hydroxy-3-methylglutaryl-coenzyme (HMG-CoA) reductase inhibitors, also known as statins, are the most effective class of drugs for lowering serum low-density lipoprotein cholesterol concentrations. They are first-line agents for patients who require drug therapy to reduce serum low-density lipoprotein cholesterol concentrations. The purpose of this review is to compare the benefits and harms of different statins in adults and children with hypercholesterolemia.

Drug Class Reviews – Oregon Health & Science University.
Version: November 2009
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Single-dose oral celecoxib for postoperative pain

Acute pain is often felt soon after injury. Most people who have surgery have moderate or severe pain afterwards. People with pain are used to test pain killers. They have often had wisdom teeth removed. The pain is often treated with pain killers given by mouth. Results can then be applied to other forms of acute pain.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: October 22, 2013

Lipid-lowering agents for nephrotic syndrome

Nephrotic syndrome is a relatively rare disease in which the kidneys leak protein into the urine. A common early sign is swelling in the feet and face. Other signs and symptoms of nephrotic syndrome include low levels of protein in the blood, and high levels of fats in the blood, particularly cholesterol and triglycerides.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: December 10, 2013

Drug and nutritional treatment for McArdle disease

We reviewed the evidence about the effects of drug and nutritional treatment for McArdle disease.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: November 12, 2014

Statins can help reduce risk of death in people with chronic kidney disease who do not need dialysis

Adults with chronic kidney disease (CKD) have high risks of developing complications from heart disease. It is thought that statin treatment lowers cholesterol and reduces risk of death and complications from heart disease.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: May 31, 2014

Screening for Lipid Disorders in Adults: Selective Update of 2001 US Preventive Services Task Force Review [Internet]

Both the US Preventive Services Task Force (USPSTF) and the National Cholesterol Education Program (NCEP ATP III) have issued recommendations on screening for dyslipidemia in adults. To guide the USPSTF in updating its 2001 recommendations, we reviewed evidence relevant to discrepancies between these recommendations.

Evidence Syntheses – Agency for Healthcare Research and Quality (US).
Version: June 2008
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The harmful health effects of recreational ecstasy: a systematic review of observational evidence

Street drugs known as ecstasy have been sold for about 20 years in the UK. The active substance that such tablets contain or purport to contain is 3,4-methylenedioxymethamphetamine (MDMA). Shortly after consumption, MDMA releases chemicals in the brain that tend to bring about a sense of euphoria, exhilaration and increased intimacy with others. It is thought to be the third most commonly used illegal drug in the UK after cannabis and cocaine, with estimates suggesting that between 500,000 and 2 million tablets are consumed each week. Most people who take ecstasy also use other legal and illegal drugs, sometimes at the same time. Ecstasy is commonly taken in nightclubs and at parties and is very often associated with extended sessions of dancing.

NIHR Health Technology Assessment programme: Executive Summaries – NIHR Journals Library.
Version: 2009

A systematic review and economic evaluation of statins for the prevention of coronary events

This study evaluated the use of a group of statins, atorvastatin, fluvastatin, pravastatin, rosuvastatin and simvastatin, for the prevention of cardiovascular events.

NIHR Health Technology Assessment programme: Executive Summaries – NIHR Journals Library.
Version: 2007

Lipid Screening in Childhood and Adolescence for Detection of Familial Hypercholesterolemia: A Systematic Evidence Review for the U.S. Preventive Services Task Force [Internet]

Familial hypercholesterolemia (FH) is an inherited disorder of lipoprotein metabolism characterized by highly elevated total cholesterol (TC) concentrations early in life, independent of environmental influences. Around 1 in 200 to 1 in 500 persons in North America and Europe are estimated to have heterozygous FH. When untreated, FH is associated with a high incidence of premature clinical atherosclerotic cardiovascular disease.

Evidence Syntheses – Agency for Healthcare Research and Quality (US).
Version: August 2016
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Daptomycin for Methicillin-Resistant and Methicillin-Sensitive Staphylococcus Aureus Infection: A Review of Clinical Effectiveness, Cost-Effectiveness and Guidelines [Internet]

The aim of this review is to summarize evidence on the comparative clinical and cost effectiveness of daptomycin to other antibiotics for the treatment of bacteremia and other infections caused by methicillin susceptible staphylococcus aureus (MSSA) or methicillin resistant staphylococcus aureus (MRSA), and to summarize evidence-based guidelines regarding the use of daptomycin for MRSA and MSSA bacteremia or infection.

Rapid Response Report: Summary with Critical Appraisal – Canadian Agency for Drugs and Technologies in Health.
Version: January 21, 2016
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Lipid Screening in Childhood for Detection of Multifactorial Dyslipidemia: A Systematic Evidence Review for the U.S. Preventive Services Task Force [Internet]

For purposes of this report, multifactorial dyslipidemia refers to dyslipidemias involving elevated total cholesterol (TC) or low-density lipoprotein cholesterol (LDL-C) that are not familial hypercholesterolemia (FH). There is evidence that elevated TC and LDL-C concentrations in childhood, and especially adolescence, are associated with markers of atherosclerosis in young adults.

Evidence Syntheses – Agency for Healthcare Research and Quality (US).
Version: August 2016
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Screening for Dyslipidemia in Younger Adults: A Systematic Review to Update the 2008 U.S. Preventive Services Task Force Recommendation [Internet]

This review updates prior reviews on screening for lipid disorders in adults, and will be used by the U.S. Preventive Services Task Force (USPSTF) to update its 2008 recommendation. Unlike prior USPSTF reviews, this one focuses on screening in younger adults, defined as adults ages 21 to 39 years, as there is more uncertainty about the need to perform lipid screening in this population than in older adults.

Evidence Syntheses – Agency for Healthcare Research and Quality (US).
Version: November 2016
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Chronic Kidney Disease (Partial Update): Early Identification and Management of Chronic Kidney Disease in Adults in Primary and Secondary Care

The Renal National Service Framework (NSF), and the subsequent NICE Clinical Practice Guideline for early identification and management of adults with chronic kidney disease (CKD) in primary and secondary care (CG73), served to emphasise the change in focus in renal medicine from treatment of established kidney disease to earlier identification and prevention of kidney disease.

NICE Clinical Guidelines – National Clinical Guideline Centre (UK).
Version: July 2014
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Guidelines for the Prevention, Care and Treatment of Persons with Chronic Hepatitis B Infection

These are the first World Health Organization (WHO) guidelines for the prevention, care and treatment of persons living with chronic hepatitis B (CHB) infection, and complement similar recently published guidance by WHO on the prevention, care and treatment of infection due to the hepatitis C virus (HCV).

World Health Organization.
Version: March 2015
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Management of Gout [Internet]

To review the evidence base for treating patients with gout, both acute attacks and chronic disease. The review specifically focuses on the management of patients with gout in the primary care setting.

Comparative Effectiveness Reviews – Agency for Healthcare Research and Quality (US).
Version: March 2016
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Spinal Injury: Assessment and Initial Management

The scope of this guideline is the assessment, imaging and early management of spinal injury and does not address rehabilitation. It is important to recognise that early management is intrinsically connected to rehabilitation and some later complications may be avoided with changes in early care. Early and ongoing collaborative multidisciplinary care across a trauma network is vital in ensuring that the patient with a spinal injury receives the best possible care.

NICE Guideline – National Clinical Guideline Centre (UK).
Version: February 2016
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Major Trauma: Assessment and Initial Management

This guideline provides guidance on the assessment and management of major trauma, including resuscitation following major blood loss associated with trauma. For the purposes of this guideline, major trauma is defined as an injury or a combination of injuries that are life-threatening and could be life changing because it may result in long-term disability. This guideline covers both the pre-hospital and immediate hospital care of major trauma patients but does not include any management after definitive lifesaving intervention. It has been developed for health practitioners and professionals, patients and carers and commissioners of health services.

NICE Guideline – National Clinical Guideline Centre (UK).
Version: February 2016
Show search results within this document

Fractures (Complex): Assessment and Management

Two of the five guidelines in the NICE Trauma Suite relate to fractures. These are titled non-complex and complex fractures. In broad terms the non-complex fractures are those likely to be treated at the receiving hospital, whereas the complex fractures require transfer or the consideration of transfer of the injured person to a specialist centre.

NICE Guideline – National Clinical Guideline Centre (UK).
Version: February 2016
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Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for advanced recurrent or refractory ovarian cancer: a systematic review and economic evaluation

The study was unable to compare the clinical and cost-effectiveness of platinum-based therapies with non-platinum-based therapies for platinum sensitive ovarian cancer. In people with platinum-sensitive disease, paclitaxel plus platinum could be considered cost-effective compared with platinum therapies alone at a threshold of 30,000 per additional quality-adjusted life-year. In people with disease which is resistant or refractory to platinum it is unlikely that topotecan would be considered cost-effective compared with pegylated liposomal doxorubicin hydrochloride.

Health Technology Assessment – NIHR Journals Library.
Version: January 2015
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Alcohol Use Disorders: Diagnosis and Clinical Management of Alcohol-Related Physical Complications [Internet]

Alcohol is the most widely used psychotropic drug in the industrialised world; it has been used for thousands of years as a social lubricant and anxiolytic. In the UK, it is estimated that 24% of adult men and 13% of adult women drink in a hazardous or harmful way. Levels of hazardous and harmful drinking are lowest in the central and eastern regions of England (2124% of men and 1014% of women). They are highest in the north (2628% of men, 1618% of women). Hazardous and harmful drinking are commonly encountered amongst hospital attendees; 12% of emergency department attendances are directly related to alcohol whilst 20% of patients admitted to hospital for illnesses unrelated to alcohol are drinking at potentially hazardous levels. Continued hazardous and harmful drinking can result in dependence and tolerance with the consequence that an abrupt reduction in intake might result in development of a withdrawal syndrome. In addition, persistent drinking at hazardous and harmful levels can also result in damage to almost every organ or system of the body. Alcohol-attributable conditions include liver damage, pancreatitis and the Wernickes encephalopathy. Key areas in the investigation and management of these conditions are covered in this guideline.

NICE Clinical Guidelines – National Clinical Guideline Centre (UK).
Version: 2010
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The Management of Lower Urinary Tract Symptoms in Men [Internet]

The guideline covers men (18 and over) with a clinical working diagnosis of lower urinary tract symptoms (LUTS). Options for conservative, pharmacological, surgical, and complementary or alternative treatments are considered in terms of clinical and cost effectiveness.

NICE Clinical Guidelines – National Clinical Guideline Centre (UK).
Version: 2010
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Reslizumab (Cinqair) [Internet]

Asthma is a common chronic respiratory disorder characterized by reversible airway obstruction, pulmonary inflammation, airway hyper-responsiveness, and airway remodelling., Patients with asthma typically present with paroxysmal or persistent symptoms of wheezing, dyspnea, chest tightness, sputum production, and coughing that are associated with airflow limitation and airway hyper-responsiveness to endogenous and exogenous stimuli (e.g., exercise; viral respiratory infections; or exposure to certain allergens, irritants, or gases). Severe eosinophilic asthma is an asthma phenotype characterized by the presence of eosinophils in the airways and sputum, despite compliance with conventional asthma therapy. Severe asthma can have a profound effect on patients day-to-day lives, such as limiting physical activity, reducing performance at work or school, restricting social interactions, and leading to stigma. It may also necessitate frequent physician and emergency room visits.

Common Drug Review – Canadian Agency for Drugs and Technologies in Health.
Version: April 2017
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When To Suspect Child Maltreatment

This guidance provides a summary of the clinical features associated with maltreatment (alerting features) that may be observed when a child presents to healthcare professionals. Its purpose is to raise awareness and help healthcare professionals who are not specialists in child protection to identify children who may be being maltreated. It does not give healthcare professionals recommendations on how to diagnose, confirm or disprove child maltreatment.

NICE Clinical Guidelines – National Collaborating Centre for Women’s and Children’s Health (UK).
Version: July 2009
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Identification and Management of Familial Hypercholesterolaemia (FH) [Internet]

While the NHS in England and Wales has made spectacular progress in improving the secondary prevention of cardiovascular disease, we now need to work harder to identify those who are at particularly high risk of myocardial infarction.

NICE Clinical Guidelines – National Collaborating Centre for Primary Care (UK).
Version: August 2008
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Lomitapide (Juxtapid) [Internet]

The objective of this review is to evaluate the beneficial and harmful effects of lomitapide added to other lipid-lowering therapy in patients with homozygous familial hypercholesterolemia (HoFH).

Common Drug Review – Canadian Agency for Drugs and Technologies in Health.
Version: July 2015
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Optimal strategies for monitoring lipid levels in patients at risk or with cardiovascular disease: a systematic review with statistical and cost-effectiveness modelling

The study found that regular lipid monitoring in individuals with and without cardiovascular disease is likely to be beneficial to both patients and to the health service, and frequent monitoring strategies appear to be cost-effective.

Health Technology Assessment – NIHR Journals Library.
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Noninvasive Testing for Coronary Artery Disease [Internet]

This report evaluates the current state of evidence regarding effectiveness and harms of noninvasive technologies for the diagnosis of coronary artery disease (CAD) or dysfunction that results in symptoms attributable to myocardial ischemia in stable symptomatic patients who have no known history of CAD.

Comparative Effectiveness Reviews – Agency for Healthcare Research and Quality (US).
Version: March 2016
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Major Trauma: Service Delivery

A trauma service provides care for people who have sustained physical injuries. These injuries are often the result of an accident but can be sustained in other circumstances. Injuries range from minor to serious life-threatening trauma. The scope of this guidance is the delivery of services for people with major trauma in the initial phase of care, exploring areas of uncertainty and variation.

NICE Guideline – National Clinical Guideline Centre (UK).
Version: February 2016
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Fractures (Non-Complex): Assessment and Management

Two of the five guidelines in the NICE trauma suite relate to fractures. These are titled non-complex and complex fractures. In broad terms, non-complex fractures are those likely to be treated at the receiving hospital, whereas complex fractures require transfer or the consideration of transfer of the injured person to a specialist.

NICE Guideline – National Clinical Guideline Centre (UK).
Version: February 2016
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Antisocial Behaviour and Conduct Disorders in Children and Young People: Recognition, Intervention and Management

Antisocial behaviour and conduct disorders are the most common reason for referral to child and adolescent mental health services and have a significant impact on the quality of life of children and young people and their parents and carers. Rates of other mental health problems (including antisocial personality disorder) are considerably increased for adults who had a conduct disorder in childhood. This new NICE guideline seeks to address these problems by offering advice on prevention strategies, as well as a range of psychosocial interventions.

NICE Clinical Guidelines – National Collaborating Centre for Mental Health (UK).
Version: 2013
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Meta-analysis of safety of the coadministration of statin with fenofibrate in patients with combined hyperlipidemia

Addition of fenofibrate to statin therapy might represent a viable treatment option for patients whose high risk for coronary heart disease is not controlled by a statin alone. However, safety of coadministration of statin with fenofibrate has been a great concern. The present study tested the safety of coadministration of statin with fenofibrate. We systematically searched the literature to identify randomized controlled trials examining safety of coadministration of statin with fenofibrate. A meta-analysis was performed to estimate safety of coadministration of statin with fenofibrate using fixed-effects models. There were 1,628 subjects in the identified 6 studies. Discontinuation attributed to any adverse events (4.5% vs 3.1%, p = 0.20), any adverse events (42% vs 41%, p = 0.82), adverse events related to study drug (10.9% vs 11.0%, p = 0.95), and serious adverse events (2.0% vs 1.5%, p = 0.71) were not significantly different in the 2 arms. Incidence of alanine aminotransferase and/or aspartate aminotransferase =3 times upper limit of normal in the combination therapy arm was significantly higher than in the statin monotherapy arm (3.1% vs 0.2%, p = 0.0009). In the 6 trials with 1,628 subjects no case of myopathy or rhabdomyolysis was reported. In conclusion, statin-fenofibrate combination therapy was tolerated as well as statin monotherapy. Physicians should consider statin-fenofibrate combination therapy to treat patients with mixed dyslipidemia.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2012

Efficacy and safety evaluation of intensive statin therapy in older patients with coronary heart disease: a systematic review and meta-analysis

PURPOSE: To reveal and evaluate the efficacy and safety of intensive statin therapy in older patients (age = 65 years) with coronary heart disease (CHD).

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2013

A systematic review and economic evaluation of statins for the prevention of coronary events

OBJECTIVES: To evaluate the clinical effectiveness and cost-effectiveness of statins for the primary and secondary prevention of cardiovascular events in adults with, or at risk of, coronary heart disease (CHD).

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2007

Risks associated with statin therapy: a systematic overview of randomized clinical trials

This review evaluated the risk of adverse events among patients taking statins. The authors concluded that statin therapy in carefully selected patients is associated with low adverse event rates in clinical trials. The reliability of the results is unclear given the lack of detail about the review process and potential for bias.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2006

Primary prevention of cardiovascular mortality and events with statin treatments: a network meta-analysis involving more than 65,000 patients

This review concluded that statin treatment used for the primary prevention of cardiovascular disease was effective in reducing cardiovascular death and other major cardiovascular events. The conduct and reporting of the review were good and the conclusions are likely to be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2008

Intensive statin therapy compared with moderate dosing for prevention of cardiovascular events: a meta-analysis of >40,000 patients

This review found that intensive dosing with statins for prevention of cardiovascular events was associated with significant reductions in non-fatal events. The review was well conducted and the authors’ conclusions are likely to be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2011

Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90 056 participants in 14 randomised trials of statins

This prospective meta-analysis of individual patient data concluded that statin therapy can safely reduce the 5-year incidence of major coronary events, coronary revascularisation and stroke by about 20% per mmol/L reduction in cholesterol, largely irrespective of lipid profile or other characteristics. The authors’ conclusions reflect the evidence presented and are likely to be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2005

Meta-analysis of drug-induced adverse events associated with intensive-dose statin therapy

The authors concluded that intensive-dose statin therapy significantly reduced the risk of a serious cardiovascular event but increased the risk of a statin-induced adverse event, compared with moderate dose therapy. The reliability of these conclusions is uncertain due to methodological weaknesses in the review such as failure to assess study validity or check for heterogeneity between the studies.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2007

Efficacy and safety of statin treatment for cardiovascular disease: a network meta-analysis of 170 255 patients from 76 randomized trials

This review concluded that statin therapies offered clear benefits in reducing cardiovascular outcomes across broad populations. The review appeared generally well conducted. The authors conclusions appear likely to be reliable, although it should be borne in mind that subgroup analysis by population type was conducted only for the primary outcome of cardiovascular disease mortality.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2011

The effect of early, intensive statin therapy on acute coronary syndrome: a meta-analysis of randomized controlled trials

This review investigated the effects of early intensive statin therapy for acute coronary syndrome. It concluded that early treatment reduces cardiovascular events with benefits observed after 6 months, but an analysis of individual patient data is needed to confirm these findings. The pooled results should be regarded with some caution because of limitations such as the variation between study results.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2006

Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials

This meta-analysis of individual patient data found that reducing low-density lipoprotein cholesterol with statins reduced the annual rate of heart attack, revascularisation and stroke by about 20% for each 1mmol/litre reduction achieved. These conclusions reflected the strong evidence presented and are likely to be reliable and applicable to a wide range of patients.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2010

Meta-analysis of cardiovascular outcomes trials comparing intensive versus moderate statin therapy

The authors concluded that intensive statin treatment offers greater benefits than standard-dose treatment, mainly for nonfatal cardiovascular events. The review appears to support the authors’ conclusions, but the poor reporting of review methods and the lack of an assessment of study quality mean that the reliability of the conclusions is uncertain.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2006

The clinical and cost-effectiveness of intensive versus standard lipid lowering with statins in the prevention of cardiovascular events amongst patients with acute coronary syndromes: a systematic review

Early intensive lipid lowering with high-dose/potency statins for high risk acute coronary syndrome (ACS) patients significantly reduced the risk of death or major cardiovascular event in comparison with standard lipid lowering regimens. The authors’ conclusion is reasonable, but perhaps should be tempered as it was primarily based on one large trial and generalisability beyond that intervention might be premature.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2007

Strength of evidence for perioperative use of statins to reduce cardiovascular risk: systematic review of controlled studies

This review determined the evidence on the use of statins during the peri-operative period to reduce the risk of cardiovascular events. The authors concluded that there was insufficient evidence for routine administration of statins to reduce peri-operative cardiovascular risk. Given the limitations of the evidence base, this conclusion seems reasonable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2006

Effects of early treatment with statins on short-term clinical outcomes in acute coronary syndromes: a meta-analysis of randomized controlled trials

This review assessed the effects of starting statin therapy within 14 days of the onset of acute coronary syndrome. The authors concluded that early statin therapy does not reduce death, myocardial infarction or stroke up to 4 months, but may reduce unstable angina. This was a well-conducted and clearly reported review and the authors’ conclusions are likely to be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2006

Comparison of sequential rosuvastatin doses in hypercholesterolaemia: a meta-analysis of randomised controlled trials

This review provided evidence for improved efficacy, as assessed by surrogate markers, in treating patients with hypercholesterolaemia with each sequential titration of rosuvastatin and a generally consistent tolerability profile across the dose range. The authors’ conclusions reflect the evidence presented, but the lack of validity assessment and lack of reporting of some data made the reliability of the conclusions uncertain.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2010

Systematic review: comparative effectiveness and harms of combinations of lipid-modifying agents and high-dose statin monotherapy

This review concluded that there was insufficient evidence to support the benefit for mortality, myocardial infarction, stroke, and revascularisation procedures of statin combination therapy over high-dose monotherapy in high-risk patients needing intensive lipid-lowering therapy. The authors’ conclusion reflected the evidence presented, but the reliability is potentially compromised by search restrictions and unclear quality of included studies.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2009

Results: 10

Is continuous renal replacement therapy beneficial for people with rhabdomyolysis?

Rhabdomyolysis is a potentially life-threatening condition where damaged muscle tissue breaks down quickly, and products of damaged muscle cells are released into the bloodstream. Of these products, a protein called myoglobin is harmful to kidney health and can lead to acute kidney injury. There is some evidence to suggest that continuous renal replacement therapy (CRRT) may provide benefits for people with rhabdomyolysis.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: June 15, 2014

When is it worth taking statins to lower high cholesterol?

High cholesterol levels could mean an increased risk of cardiovascular disease. Certain medications called statins lower the amount of cholesterol in the blood. They can prevent related medical conditions and increase life expectancy. Whether or not it’s worth taking them will depend on what other risk factors you have, though. If the risk of cardiovascular disease can’t be reduced enough through general measures, treatment with medication can be considered. Whether treatment with medication is a good idea will mostly depend on individual risk factors and how you yourself view the pros and cons of the treatment. The main factor is whether you have already had cardiovascular disease, such as coronary artery disease. That may greatly increase the risk of a heart attack or stroke. This risk can be reduced using medication. When deciding whether or not to have a certain treatment, it can help to find out about the advantages and disadvantages of the treatment. Various groups of drugs can be used for the treatment of high cholesterol. But only one group of drugs, known as statins, has been well studied in people who have never had a heart attack, stroke or other type of cardiovascular disease. Many different statins have been approved in Germany, including atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin and simvastatin.

Informed Health Online [Internet] – Institute for Quality and Efficiency in Health Care (IQWiG).
Version: September 7, 2017

Medication for the long-term treatment of coronary artery disease

The long-term treatment of coronary artery disease (CAD) mainly involves taking medication. Various medications can relieve the symptoms and lower the risk of complications. In order to prevent the development of related medical conditions, all people who have coronary artery disease (CAD) are advised to take two types of medication: Antiplatelets to prevent blood clots, and statins to protect the blood vessels. Beta blockers are sometimes taken too, to reduce the heart’s workload, particularly in people who have heart failure or high blood pressure. Good-quality studies have proven that these medications can lower the risk of complications such as heart attacks or strokes. People who have certain other medical conditions too may take other medications such as ACE inhibitors. But even the very best treatment with medications will offer only limited protection from heart disease. All medications can have side effects. Yet it is often possible to avoid them by adjusting the dose or by choosing a different medication in the same group of drugs. The side effects often go away after a while too, once the body has got used to the medication. The risk of side effects may increase when two or more medications are taken together, because they may interact. It is therefore important to tell your doctor what medication you are already taking. Generally speaking, the more risk factors someone has, the more likely it is that he or she will benefit from medication. The important thing is to continue to take your medication and to take it regularly its protective effect lasts only as long as it is taken.

Informed Health Online [Internet] – Institute for Quality and Efficiency in Health Care (IQWiG).
Version: July 27, 2017

Aerobic training for McArdle disease

McArdle disease is a rare disease of muscle metabolism. Affected people cannot use a starch-like substance called glycogen which is stored in muscle and used for energy at the beginning of activity and during strenuous exercise. The effects of the condition are fatigue and cramping within a few minutes of starting an activity, which can potentially lead to acute muscle damage. After about seven or eight minutes of exercise the muscle can start to use alternative sources of energy from fats and sugars supplied from the liver and so the symptoms ease. This phenomenon is called the ‘second wind’. In healthy people, aerobic training is known to improve the ability of muscle to burn fats for energy during exercise. In theory then, aerobic training could be beneficial to people with McArdle disease, as their muscles might be trained to use fats earlier and more efficiently during exercise. The purpose of this review was to identify any randomised controlled trials of aerobic training and assess its effects in people with McArdle disease. There were no randomised controlled trials of aerobic training in people with McArdle disease. There were, however, three small uncontrolled studies (the largest included nine participants). The studies showed that it is possible for people with McArdle disease to undergo exercise training and there were no harmful effects. Whether or not training is beneficial for people with McArdle disease needs further investigation, with randomised controlled trials including larger numbers of people with the condition.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: December 7, 2011

Statins for acute ischemic stroke

Stroke is a major public health problem than can cause death and severe disability. A limited number of drugs are available for treating patients with stroke. Statins, a group of drugs commonly used to reduce cholesterol levels, are known to be safe and effective when given to patients with an acute heart attack. Therefore, they may also be beneficial in patients with acute stroke. We identified eight relevant trials of statins in acute stroke involving 625 participants. Unfortunately, insufficient information was available to establish whether statins are safe and beneficial for patients with acute ischemic stroke

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: August 10, 2011

Single-dose oral celecoxib for postoperative pain

Acute pain is often felt soon after injury. Most people who have surgery have moderate or severe pain afterwards. People with pain are used to test pain killers. They have often had wisdom teeth removed. The pain is often treated with pain killers given by mouth. Results can then be applied to other forms of acute pain.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: October 22, 2013

Lipid-lowering agents for nephrotic syndrome

Nephrotic syndrome is a relatively rare disease in which the kidneys leak protein into the urine. A common early sign is swelling in the feet and face. Other signs and symptoms of nephrotic syndrome include low levels of protein in the blood, and high levels of fats in the blood, particularly cholesterol and triglycerides.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: December 10, 2013

Drug and nutritional treatment for McArdle disease

We reviewed the evidence about the effects of drug and nutritional treatment for McArdle disease.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: November 12, 2014

Statins can help reduce risk of death in people with chronic kidney disease who do not need dialysis

Adults with chronic kidney disease (CKD) have high risks of developing complications from heart disease. It is thought that statin treatment lowers cholesterol and reduces risk of death and complications from heart disease.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: May 31, 2014

Comparing Statins and Combination Drugs

How do statins and combination drugs compare in lowering “bad” cholesterol (LDL-c)?

PubMed Clinical Q&A [Internet] – National Center for Biotechnology Information (US).
Version: November 1, 2010

https://www.ncbi.nlm.nih.gov/pubmedhealth/c/pmh_cons/?term=rhabdomyolysis

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What’s to know about rhabdomyolysis?

Last reviewed Wed 5 July 2017

By Jennifer Huizen

Medical News Today

https://www.medicalnewstoday.com/articles/318224.php

Article Contents

What is rhabdomyolysis?

Causes

Symptoms

Diagnosis

Treatment

Preventing rhabdomyolysis

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Rhabdomyolysis

Updated: Nov 10, 2017

Author

Eyal Muscal, MD, MS Assistant Professor, Section of Pediatric Immunology, Allergy, and Rheumatology, Department of Pediatrics, Baylor College of Medicine, Texas Children’s Hospital

Eyal Muscal, MD, MS is a member of the following medical societies: Alpha Omega Alpha, American College of Rheumatology

Disclosure: Nothing to disclose.
Coauthor(s)

Marietta Morales De Guzman, MD Associate Professor, Section of Immunology, Allergy and Rheumatology, Department of Pediatrics, Baylor College of Medicine; Clinic Chief, Pediatric Rheumatology Center, Texas Children’s Hospital

Marietta Morales De Guzman, MD is a member of the following medical societies: American Academy of Pediatrics, American College of Rheumatology, Texas Pediatric Society

Disclosure: Nothing to disclose.
Chief Editor

Lawrence K Jung, MD Chief, Division of Pediatric Rheumatology, Children’s National Medical Center

Medscape

https://emedicine.medscape.com/article/1007814-overview

In most cases, the history reflects the inciting cause (though in some, it is nonspecific and thus diagnostically unreliable). Possible causes include the following:

Alcohol use and resultant unresponsiveness

Illicit drug use

Use of prescribed medications

Heatstroke

Infection

Trauma

Metabolic disorders

Inflammatory myopathies

Initial physical findings may be nonspecific. The following may be noted:

Muscular pain and tenderness

Decreased muscle strength

Soft tissue swelling

Skin changes consistent with pressure necrosis

Hyperthermia, hypothermia, and electrical injuries

Crush injuries or deformities in long bones

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Rhabdomyolysis and Acute Kidney Injury | NEJM

https://www.nejm.org/doi/full/10.1056/nejmra0801327

by X Bosch – ?2009 – ?Cited by 847 –
May 18, 2011 – Review Article from The New England Journal of Medicine Rhabdomyolysis and Acute Kidney Injury.

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Rhabdomyolysis – Mayo Clinic – YouTube
Video for rhabdomyolysis
? 2:25

https://www.youtube.com/watch?v=Hy0uEPo8-7w

Jun 22, 2011 – Uploaded by Mayo Clinic
Earlier this year, thirteen football players from the University of Iowa were hospitalized with Rhabdomyolysis …

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Sincerely,
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Temple University
(215) 204 – 4584
jwne@…

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MEDICAL: DISEASES : PHYSICAL EXERCISE AND FITNESS : CHILDREN: A Teen’s Muscle Soreness Turned Out to Be This Life-Threatening Condition